Improve model initialization and priors#46
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logan-blaine merged 11 commits intomainfrom May 19, 2025
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logan-blaine
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May 12, 2025
logan-blaine
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- Improve gene mean/dispersion estimation
- Fit guide efficiency independently across genes (prevents collapsing values when total number of genes is large)
- Fix total_counts/logits parameterization so that log_gene_mean accurately represents the per-cell mean
- Optionally allow mean-dispersion trend fitting to see if this helps
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